Since 2000, the Québec Survey on Smoking, Alcohol, Drugs and Gambling in High School Students has provided information on three types of psychoactive substances popular with students: cannabis (marijuana, pot, hashish), hallucinogens (LSD, PCP, MESS, magic mushrooms, acid, mescaline, ecstasy, blotters, etc.) and amphetamines (speed, uppers). By focusing on students in Secondary 3, 4 and 5, this bulletin provides additional insight to the survey report published in 2007. It presents a portrait of the use of these substances among this subgroup of students and traces the evolution of their use. The main factors associated with substance use, such as gender, language spoken at home, family structure, employment, weekly allowance and self-evaluation of school performance, are taken into account in the analyses.